KrosFlo® TFF Systems
Turnkey systems for tangential flow filtration (TFF), KrosFlo® Systems are compatible with single-use hollow fiber filters and/or flat sheet cassettes, modernizing how UF/DF is performed at every stage from process development to large-scale manufacturing.
Discover your next KrosFlo® Tangential Flow Filtration System
Automated tangential flow filtration systems for bench scale from 5mL - 500L
Foundational to research and process development laboratories globally, KrosFlo® KR2i, KMPi, and FS systems are proven and intuitive TFF solutions for testing and optimizing procedures for scale up.
KrosFlo® KR2i TFF System
Single-use fully integrated benchtop TFF system for research and process development (PD) ranging from 2mL - 15L. Compatible with hollow fiber and flat sheet filters, this system features a peristaltic feed pump with 13 automated process modes.
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KrosFlo® KMPi TFF System
Fully automate 100 ml - 500 L UF/DF processes using an unparalleled combination of hardware integration with peristaltic pump, configurability and automation through modular, plug-and-play hardware.
Automated tangential flow filtration for pilot scale 200L - 5000L
Trusted for gentle processing of shear sensitive biologics like lipid nanoparticles (LNPs) for pilot scale and manufacturing.
KrosFlo® KTF TFF Systems
The KrosFlo KTF are a series of highly configurable single-use TFF systems for multiple unit operations, applications, and filter types. With volumes spanning across 1 to 5000L, users enjoy the unrivaled flexibility of processing large and small batch sizes within the same platform.
Fully automated TFF systems for GMP manufacturing 35mL - 2000L
Ideal for mRNA and gene therapy production, KrosFlo® RS TFF are out most advanced series of fully automated TFF systems built for GMP manufacturing. Customization available upon request.
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
PAT-Driven Control with Real-Time Concentration Analytics
Introducing our groundbreaking Real-time Process Management (RPM™) line of TFF instruments, a cutting-edge solution designed to revolutionize process control in tangential flow filtration (TFF) systems. At the core of this innovation lies the integration of the CTech™ FlowVPX® in-line UV-Vis spectrophotometer into our KrosFlo® TFF Systems, providing users with unprecedented real-time insights and control over ultrafiltration/diafiltration (UF/DF) processes during downstream bioprocess development.
Real-time Process Management Solutions
Our Real-time Process Management (RPM™) Systems establish a new benchmark for real-time process control in downstream bioprocessing by integrating of the CTech™ FlowVPX® in-line UV-Vis spectrophotometer into the KrosFlo® TFF Systems. This innovative solution empowers users to achieve unparalleled control and optimization of UF/DF processes, driving efficiency, quality, and innovation in biomanufacturing.
Why choose KrosFlo® Tangential Flow Filtration systems?
Repligen is a leader in Tangential Flow Filtration technologies, offering systems that combine cutting-edge innovation, reliable performance, and flexible scalability. By choosing our TFF systems, you can optimize your bioprocesses to maximize yields and increase operational efficiency.
New to the topic? Read more on Tangential Flow Filtration: A Complete Guide for Bioprocessing Professionals.