KF Comm 2 Software

Proprietary, menu-driven software is optimized for use with KrosFlo^® KR2i, KrosFlo^® KMPi and KrosFlo^® FS Tangential Flow Filtration Systems.

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OPTIMIZED

For use with KrosFlo^® KR2i and KrosFlo^® KMPi TFF Systems

21 CFR Part 11 option

For validation of GMP processes

OPTIMIZED

Menu-driven Software for Optimized TFF

KF Comm 2 Software, backward compatible with legacy KrosFlo^® KR2i and KrosFlo^® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.

Proprietary software optimized for KrosFlo^®TFF Systems
Validated for GMP Processes with optional 21 CFR Part 11 option
Intuitive workflow with 13 modes of operation

21 CFR Part 11 option

Optional GMP Validation

KF Comm 2 software may be validated for GMP processes with optional 21 CFR Part 11 compliance.

Available for customers that require the system to be validated for GMP processes
Includes user-specific access control via an administration console
Login module with electronic signature that logs when the user is running experiments and accessing archived data
Audit Trail /Auditor role

KF Comm 2 Software

KF Comm 2 Software

Automatically collects process data
Provides real-time overviews of the filtration process

Microsoft Surface Pro 4

Automatically graphs data and trends in the software

Real-time operating parameters

Time
Feed Pressure
Retentate Pressure
Permeate Pressure
Feed Flow Rate
Diafiltration Flow Rate
Permeate Flow Rate
Feed Scale Weight
Permeate Scale Weight
Pump RPM
Notes (Alarms, Process status, Functions)
Pump Mode

Processing parameters

Transmembrane Pressure (TMP)
Pressure Drop (ΔP)
Retentate Flow Rate
Permeate Flux
Volumetric Throughput (VT)
Concentration Factor
Shear
Diafiltration Volumes
Process Time
UV, Conductivity, and Temperature (with KONDUiT)

	Process Control Modes	Primary Application
M	Manual Mode	Manual operation of pumps and auxiliary components
CONT	Continuous Mode	Manual operation of pumps and auxiliary components with operator interface step of operation (concentration and diafiltration)
C	Concentration Mode	Simple concentration of the process solution. Automated flushing of the hollow fiber filter
C/D	Concentration / Diafiltration	Concentration and then diafiltration of the process solution in succession
C/D/C	Concentration / Diafiltration / Concentration	Diafiltration of the process solution with one buffer before concentration of the process solution a second time
C/D/D/C	Concentration / Diafiltration / Diafiltration / Concentration	Diafiltration of the process solution with two different buffers in succession before concentration of the process solution a second time
CFC	Constant Feed Concentration	Concentration of the solution while maintaining a constant feed weight
CF/D/C	Constant Feed Concentration / Diafiltration / Concentration	Concentration of the solution while maintaining a constant feed weight, then washing the solution with a buffer during diafiltration, followed by further concentration of the solution
V	NEW Control mode (Vacuum Mode)	Use Constant Feed Mode and/or Diafiltration Mode without the need of auxiliary pumps. The solution is drawn into the Feed reservoir by the vacuum created in the reservoir as the solution permeates out of the filter
F	NEW Flushing Mode	Flush mode
NWP	NEW Normalized Water Permeability Mode	Used to determine filter cleanliness after cleaning and used to determine the water flux of a new module
C	NEW Cleaning Mode	Clean mode
FE	NEW Flux Excursion Mode	Measure flux rate

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