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Downstream Filtration Products

Filtration in bioprocessing aims to remove unwanted substances (such as cell debris, viruses and bacteria) from cell media and other downstream processes, to filter out the Active Pharmaceutical Ingredients (API).  

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The most common filtration applications are ultrafiltration and diafiltration using tangential flow filtration (TFF). Current needs include single-use, higher-capacity, higher-performance filters based on new materials, membrane structures, and filter designs,

Repligen provides high-performance, expertly engineered  integrated TFF systems, hollow fiber filters and flat sheet cassettes, and real-time process management and integrated single-use flow paths.

Repligen also provides hands-on process and implementation consultation from global Field Applications Specialists.

KrosFlo® TFF Systems

Turnkey systems for tangential flow filtration (TFF), KrosFlo® Systems are compatible with single-use hollow fiber filters and/or flat sheet cassettes, modernizing how UF/DF is performed at every stage from process development to large-scale manufacturing.

ProConnex® Flow Paths for Systems

Expertly designed plug-and-play flow path
 

ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility. ​

Hollow Fiber Filters

Ideal for ultrafiltration and microfiltration of shear-sensitive modalities, Spectrum® Hollow Fiber Filters for TFF can accommodate the widest range of scales, membrane chemistries and pore sizes to maximize process outcomes.

TangenX® Flat Sheet Cassettes

First-to-market with single-use TFF flat sheet cassettes, TangenX® TFF technologies are reliable, scalable, and cost-effective solutions for efficient concentration and diafiltration.

Fluid Management

Repligen offers innovative, designed-for-purpose storage and transfer solutions for fluid management within and between unit operations. These include flow paths, tubing, valves and gaskets, bottles and containers, totes, carts and cleanroom process equipment.

Laboratory Dialysis

Repligen offers the largest selection of dialysis membranes for laboratory research and analytical testing, featuring SpectraFlo® Dynamic Dialysis for Ideal for the production of fragile proteins, viscous fluids and polymer gels.

KrosFlo® KR2i RPM™ System

TFF with In-Line Protein Concentration Management

Monitor concentration in real time during your UF/DF run. Featuring in-line protein concentration management, control your process with the power of the KrosFlo® KR2i TFF System and insights from the integrated CTech™ FlowVPX® System.