Process Intensification
MORE. FASTER.
Bioprocess intensification is defined as a significant step increase in output relative to cell concentration, time, reactor volume or cost, resulting in improvements in productivity, environmental and economic metrics.
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Bioprocess intensification usually involves a drastic change in equipment and/or process design e.g., moving from batch to continuous processing or integrating new process steps. The result is not only a considerable increase in productivity but a significant improvement in other environmental and economic metrics such as energy consumption, carbon footprint, OPEX and CAPEX.
Benefits of process intensification in bioprocessing
BUSINESS
- Miniaturized plant size
- Reduced CAPEX and OPEX
- Distributed manufacturing
- Faster from research to market
PROCESS
- Higher cell densities
- Increased productivity
- Improved product CQA
- Wider process conditions
- Continuous processing
ENVIRONMENT
- Reduced energy use
- Reduced waste
- Reduced reagent usage
- Smaller landscape footprint
Repligen solutions help overcome key challenges in process intensification, with hands-on process and implementation consultation from global Field Applications Specialists.
Leader in Upstream Process Intensification
Watch the webinars on history, potential, applications
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The PAT landscape in upstream intensification, the benefits of this approach, and the scale-up from benchtop to manufacturing is discussed.
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This webinar discusses similar efficiency gains for three different viral vectors (lentivirus, AAV8 and AAV9) through intensification using KrosFlo® TFDF® Technology that resulted in reduce train vessel number, N-1 vessel size, media volume and time.
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15+ years of published application data, implementation in the largest number of commercial processes and proven scaling from 1 L to 5000 L differentiate XCell ATF® Technology from all other upstream intensification methods. Considerations for when and why to apply XCell ATF® Technology in order to meet specific productivity goals will be discussed.
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Perfusion Cell Culture
Perfusion, a cornerstone of upstream continuous bioprocessing, has been practiced since the 1980s to maximize facility utilization, expand process flexibility and minimize costs. Today, novel cell retention devices and single-use technologies, with sophisticated control logic, simplify implementation.
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