TangenX® PRO Cassettes
Designed to be cleaned and re-used multiple times, PRO and PRO PD Reusable TFF Cassettes are interchangeable with SIUS® Single-use Cassettes.
Powered by Bioz
TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
FLEXIBLE
Diverse options for diverse process needs
PRO TFF Cassettes are offered with two membrane chemistries, two screen types, a wide selection of molecular weight cutoffs (MWCO), and a broad range of surface areas. With 96 configurations available, PRO TFF Cassettes accommodate diverse process requirements for ultrafiltration and diafiltration applications from process development to commercial manufacturing.
- Neutral charge
- Low protein binding
- Excellent chemical resistance
- Hydrophilic
- Low protein binding
- minimal fouling with hydrophobic species
FLEXIBLE
Multiple channel configurations
Tangential flow filtration cassettes create turbulence at the membrane's surface and minimize fouling. The result is an increase in performance with a higher permeate flux. PRO Cassettes are offered in three different channel configurations to best suit the application. The channel configuration refers to the type of turbulence promoter incorporated into the feed channel of a cassette.
A medium channel or L screen is offered in all PRO Cassette formats. The screen creates turbulence at the membrane's surface ensuring outstanding permeate flux with minimal fouling. This channel configuration requires the lowest pumping rate and yields the highest cross flow velocity. This type of channel is best suited for clarified feed streams over a wide range of viscosities.
A coarser screen channel, the EP channel is offered in all PRO Cassettes. The screen geometry of this single-use cassette can process feed streams with a higher viscosity and reduce the overall pressure drop. It is scalable from 100cm2 to 2.5m2, packaged sanitized and compatible with existing cassette holders and FPIs. This type of channel is best suited for processes that use shear sensitive feed streams.
An open channel or J channel is offered in all PRO Cassettes. A 0.5mm flow spacer separating the membrane creates an open feed flow channel. This type of channel creates the least amount of turbulence while still minimizing fouling. It also requires the highest pumping rate to pass particulates. This type of channel is best suited for unclarified feed streams and is used for processes such as cell harvest operation.
FLEXIBLE
Compatible with most cassette holders
To ensure fit with cassette holders from other manufacturers,
PRO TFF Cassettes for process development are offered with two different notch patterns at the end of the cassette.
TangenX® PRO PD with standard notch
0.850in (21.59mm) Offset
This format fits the following cassette clamps and holders:
- TangenX® SIUS® PD Cassette Clamps
- TangenX® PRO PD Cassette Holders
- Pall - Centramate Holder (CM018LV, FS001K10)
TangenX® PRO PD with offset notch
0.756in (19.21mm) Offset
This format fits the following cassette clamps and holders:
- This format fits the following third part cassette holders:
- Sartorius - Sartocon Slice holder (17525-01, 17521-02)
- GE - Kvick Lab Holder (KLPH01SSU, KLHR0105000SS)
- Millipore - Pellicon Mini Holder (XX42PMINI)
SCALABLE
Scalable from process development to commercial scale
Process volume and membrane area determine scale-up from SIUS® Single-use Cassettes to PRO Reusable TFF Cassettes.
Single-use TFF provides the greatest benefit for small to moderate scale operations.
Reusable TFF is optimal for large production scale operations.
Interested in simulating a cost model for your specific application?
TangenX® PRO Cassettes
TangenX® PRO Reusable TFF Cassettes may be cleaned and re-used multiple times while maintaining reproducible cassette performance. They are engineered with optimized channel geometry and enhanced device rigidity to ensure that hydraulic performance is maintained during processing and scale-up.
Validated for GMP use, PRO TFF Cassettes come in two industry standard format footprints with accompanying holders. They are available using ProStream or HyStream membranes, with choice of pore size and flow-channel configuration.
Click on the tabs below to explore different features of PRO Cassettes for process development or commercial manufacturing.
During process development, scientists aim to select the most promising membrane candidates, while making related decisions regarding feed pressure, TMP and screen geometry. PRO PD Cassettes enable process development scientists to select the most promising membrane candidates.
Membrane Surface Areas:
0.01 meter2, 0.02 meter2, 0.10 meter2
When the primary membrane candidate has already been chosen as a process parameter, the production method needs to be verified and production materials produced for toxicology or pre-clinical trials, and ultimately for large-scale commercial production. TangenX® PRO TFF Cassettes provide reliable cassette-to-cassette consistency, ensuring that processes can scale to commercial production levels.
Membrane Surface Areas:
0.5 meter2, 1.5 meter2, 2.5 meter2
Solutions
TFF genius
You’re not asking for too much. Combine high selectivity and reduced processing time. Become a TFF genius and get it all with TangenX® Membranes and TFF Devices.
Manufacturing Centers of Excellence
Repligen develops and manufactures products for the biopharmaceutical industry under an ISO 9001 quality management system. We focus on the timely delivery of high quality, consistent and robust products, to ensure business continuity for our customers.
Repligen manufacturing sites are located in Massachusetts, California, and New Jersey in the United States and in Sweden, France, The Netherlands, Germany and Estonia.
Validated Manufacturing
Quality Manufacturing
TangenX® Cassettes are manufactured in a fully validated and documented manufacturing process according to the principles of cGMP. Each cassette comes with a Quality Assurance Certificate.
Comprehensive Regulatory Support Files
Each TangenX® TFF Cassette is supported by a Regulatory Support File (available upon request) that includes:
- Product information
- Cassette design
- Materials of construction
- Product performance
- Safety information
- Documentation system
- Product Manufacturing
- Qualification
- Manufacturing Process Validation
- Release Testing
Customer First.
Support is part of the Repligen DNA. Our goal is to provide exceptional customer experience, and to support the efficient and successful adoption and implementation of all Repligen products and services.
- Field Application Support
- Customer Service
- Field Service Engineers
TangenX® PRO Hardware
TX003 (Pilot Holder)
- Expands to accommodate from 0.01 to 0.5 m2 (1 to 5 ft2) of screen channel or suspended screen channel cassettes
- Available with luer lock for reduced hold up volume or mini tri-clamp connections for sanitary applications
TX034 (HC-LHV Holder with stand and 3-gauge Fitting Package)
- Enhanced drainability
- Reduced footprint and efficient use of limited laboratory space
TX032 (Horizontal Sanitary Holder Version 2)
- Expands to accommodate from 0.46 to 6 m2 (% to 50 ft2) of screen channel or suspended screen channel cassettes
- Smaller footprint means lower capital and operational costs, and efficient use of limited production space
TX005 (Vertical Sanitary Holder with Auto Torque)
- Enhanced drainability
- Available with hydraulic auto-torque closing option
- Minimizes the difficulty and time associated with loading large area systems
- Prevents cassette misalignment and potential leakage
- Single-sided vertical design allows for easy cassette installation and change
- Eliminated operator torque variability
03
KrosFlo® RS TFF Systems
The KrosFlo® RS are a series of tangential flow filtration (TFF) systems engineered for an era of new modalities. These systems are single-use and cGMP compliant with features like end-to-end automation, minimal hold-up volumes, and effortless scalability. Support automated ultrafiltration and diafiltration (UF/DF) processes for batch volume ranges of 35mL to 2000L.
ProConnex® Flow Paths for Systems
Expertly designed plug-and-play flow path
ProConnex® Flow Paths for TFF and Chromatography processes are single-use and engineered for optimum performance, reproducibility and time savings. System specific flow paths provide speed and reliability. Configured flow paths prioritize process requirements and sterility.
TangenX® SIUS® TFF Cassettes
SIUS® Cassettes are the first purpose-built single-use cassettes for tangential flow filtration, delivering unparalleled savings in filter cost, labor cost and buffer use.
TangenX SC TFF Device
TangenX® SC TFF Device: Revolutionize tangential flow filtration processes
Eliminate the hassle and inefficiency that comes with traditional downstream filtration cassette formats. Say goodbye to cassette holders, complex setups, continued torquing, wasted time, and product loss risks. Discover TangenX® SC, the future of TFF cassette solutions for ultrafiltration and diafiltration, designed to meet the demands of today’s TFF processes while dramatically reducing setup time and minimizing product loss risk.
Resources
