Elevate Your Bioprocessing with Spectrum® Hollow Fiber Filters

Unlock the full potential of your Tangential Flow Filtration (TFF) process with Repligen Spectrum^® Hollow Fiber Filters, designed to meet the demands of modern bioprocessing. With unparalleled customization, advanced membrane technology, and state-of-the-art manufacturing, our hollow fiber filters deliver the performance and reliability you need to succeed in your TFF process. Why Repligen Spectrum^® Hollow Fiber Filters? Here’s 3 reasons why.

Unmatched Customization

Spectrum Hollow Fiber Filters offer 4 membrane chemistries, 15 pore sizes, and 5 effective lengths, giving you the flexibility to tailor your filtration system precisely to your process and application needs. Whether you’re scaling up production, enhancing throughput, or maintaining consistent quality, you can find the right solution for your specific challenges.

Cutting-edge Membrane Technology

Repligen’s modified polyether sulfone (mPES) membranes deliver tight selectivity with high flux, ensuring efficient filtration while protecting delicate biomolecules. Ideal for critical applications such as Lentivirus, mRNA, pDNA, and LNPs, our advanced membrane technology reduces fouling and maximizes recovery, even under high-pressure conditions.

See popular applications

Superior Manufacturing Standards

State-of-the-art facilities, equipped with ISO 7 cleanrooms and ISO 9001 certification, ensure that every Spectrum Hollow Fiber Filter is produced with the highest standards of quality and reliability. Highly automated processes enhance throughput, minimize errors, and allow us to meet demand with competitive lead times. Need I say more? When you choose Repligen, you choose filters that consistently perform, batch after batch, helping you maintain efficiency and trust in your bioprocessing operations.

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Popular Applications of Spectrum^® Hollow Fiber

Applications	Membrane selection	mPES	PES	ME	PS
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins	3, 5, 10, 30, 50, 70,100kD	x			x
Depyrogenation of water / buffers	3, 10kD	x			x
Concentration and diafiltration of albumin (nominal MW 67kd)	10kD	x
Concentration and diafiltration of monoclonal antibodies (155kd)	30kD	x
Concentration and diafiltration of envelope and non-envelope virus	50, 70, 100, 300, 500, 750kD, 0.05µm	x			x
Clarification of cell lysates, viral-expressed cultures to recover product in permeate	500, 750kD, 0.05, 0.1µm	x		x	x
Concentration and washing of insect, bacterial and/or mammalian cells	750kD, 0.1, 0.2, 0.5, 0.65µm	x	x	x
Continuous bioreactor perfusion of cell culture	30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm	x	x
Concentration and diafiltration of single-stranded or double-stranded nucleic acids	3, 5, 10, 30, 50, 70,100kD	x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance	500, 750kD, 0.05, 0.1, 0.2, 0.65µm	x		x	x