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Hollow Fiber Filters

Ideal for ultrafiltration and microfiltration of shear-sensitive modalities, Spectrum® Hollow Fiber Filters for TFF can accommodate the widest range of scales, membrane chemistries and pore sizes to maximize process outcomes.

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 MAXIMIZED PERFORMANCE

Gentle on shear-sensitive molecules

Hollow fibers possess a smooth internal wall and tubular channel geometry, that promotes laminar flow with high flux. The low shear and turbulence of laminar flow helps maintain the integrity of shear sensitive modalities such as lentivirus.

Laminar flow

Flow is primarily straight and streamlined

 

Turbulent flow

Irregular, chaotic flow creates eddies that change flow in both magnitude and direction

 MAXIMIZED PERFORMANCE

Game-changing mPES Chemistry

Directly modified from the PES backbone

  • Uniquely formulated to provide tight selectivity without sacrificing high flux
  • Thin selective layer in the inner lumen​​
  • Significantly s more porous membrane​​
  • Robust design for high-pressure applications​​
  • Ideal for Lentivirus, mRNA, pDNA and LNPs​​
  • Maximizes recovery
  • Reduces fouling

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Membrane Applications

The following table shows typical use of membrane chemistries by application.

Applications Membrane selection mPES PES ME PS
Concentration and diafiltration (buffer exchange) of proteins, peptides, enzymes, recombinant proteins 3, 5, 10, 30, 50, 70,100kD x x
Depyrogenation of water / buffers 3, 10kD x x
Coating, diafiltration, fractionation and/or dewatering of nanoparticles 70,100,300,500,750kD, 0.2µm x x
Concentration and diafiltration of albumin (nominal MW 67kd) 10kD x
Concentration and diafiltration of monoclonal antibodies (155kd) 30kD x
Concentration and diafiltration of envelope and non-envelope virus 50, 70, 100, 300, 500, 750kD, 0.05µm x x
Clarification of cell lysates, viral-expressed cultures to recover product in permeate 500, 750kD, 0.05, 0.1µm x x x
Concentration and washing of insect, bacterial and/or mammalian cells 750kD, 0.1, 0.2, 0.5, 0.65µm x x x
Continuous bioreactor perfusion of cell culture 30, 50, 70, 100, 300, 500, 750kD, 0.2, 0.65µm x x
Concentration and diafiltration of single-stranded or double-stranded nucleic acids 3, 5, 10, 30, 50, 70,100kD x
Washing latex, polystyrene and other diagnostic particles to remove un-reactives / unbound drug substance 500, 750kD, 0.05, 0.1, 0.2, 0.65µm x x x
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 EMPHASIS ON EFFICIENCY

Emphasis on manufacturing innovation and security of supply
 

State-of-the-art facility

  • ISO 9001 certified
  • ISO 7 cleanroom

High degree of automation

  • Hight throughput
  • Consistency in quality

Competitive lead times

  • Select off-the-shelf filters
  • Available with or without gamma irradiation
  END-TO-END EXPERTISE

Leverage TFF expertise in filter selection and beyond

  • Selection of TFF format: Heavily reliant on modality
  • Screening membrane MWCO: Selection based on recovery and impurity removal
  • Final TFF condition optimization and sizing for process scale-up: Flux optimization and sizing at different scales

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Scale-up made easy

Hollow fiber filter TFF modules are offered with a broad range of sizes, surface areas and membrane chemistries designed to facilitate easy scale-up from small volume process development and R&D applications to commercial production. During scale-up, adding more fibers to process larger volumes enables consistency in the length of the filtration flow path even while the surface area of the filter is increased.

  Primary Application Volume Inlet/ Outlet Side Port Effective Length (cm) Total Length (cm) Surface area

MicroKros

              

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 Process characterization, Small-volume TFF in a laboratory 1-100 ml MLL FLL 20
41.5
65		 25
45
69		 13 – 20 cm2
26 - 59 cm2
41 - 92 cm2

MidiKros

              

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 Process development at small scale 100 ml - 3 L FLL FLL 20
41.5
65		 25
45
69		 75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MidiKros TC

              

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 Process development at pilot scale 100 ml - 3 L 1/2" TC FLL 20
41.5
65		 25
45
69		 75 – 190 cm2
155 - 390 cm2
245 - 610 cm2

MiniKros Sampler

              

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 Batch TFF of small volumes 3 L -15 L 0.75" TC 0.75" TC 20
41.5
65		 25
47
70		 490 – 1000 cm2
1000 - 2200 cm2
1600 - 3400 cm2

MiniKros

              

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 Pilot-scale TFF 5 L - 50 L 1.5" TC 0.75" TC 20
41.5
65		 25
46
70		 0.16 - 0.31 m2
0.32 - 0.65 m2
0.51 - 1.0 m2

KrosFlo®

              

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 Production-scale TFF 10 – 100L 3" TC 1.5" TC 20
41.5
65		 23
46
69		 0.78 - 1.6 m2
1.65 - 3.25 m2
2.55 - 5.10 m2

KrosFlo® MAX

              
Request a Quote Production-scale TFF 100L – 1000+L 6" TC 1.5" TC 49.9
67.9
107.5		 73.5
91.5
131.1		 4.30 - 10.40 m2
7.10 - 17.10 m2
11.30 - 11.35 m2

Configurators

Find a Spectrum Hollow Fiber Filter

Search for Spectrum Hollow Fiber Filters by Module Family, Membrane Chemistry, MWCO, and other parameters.

Hollow Fiber Calculator

Easy-to-use online Hollow Fiber Filter tool for calculating critical process parameters like Flow Rate Per Fiber, Holdup Volume, Total Surface Area, and more.

Product Number Key

To specify the hollow fiber filter specific to your application, follow the product number key below.

Click on the image highlights to see the different elements of lab-scale and commercial-scale TFF Solutions from Repligen

Complete lab-scale TFF Solution from Repligen

Complete commercial-scale TFF Solution from Repligen

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