SoloVPE Application: Drug-to-Antibody Ratio (DAR)

The SoloVPE System provides accurate, precise, and robust concentration measurements of Antibody-Drug Conjugates (ADCs) and Drug-to-Antibody Ratio (DAR).

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Measure Antibody Drug Conjugates with VPT

Accurately measure antibody drug conjugates

CTech^™ SoloVPE^™ System can be used to accurately measure Antibody Drug Conjugates (ADC) by using variable pathlength technology.

Challenges

There is potential for miscalculation due to optical density being affected by dilution and manual calculation when using traditional ultraviolet and visible (UV‐Vis) absorption spectroscopy methods.

The SoloVPE Solution

Allows users to get an accurate drug-to-antibody Ratio (DAR) value by measuring the payload and antibody wavelength simultaneously.
Slope Spectroscopy manipulates Beer-Lambert’s law, allowing the system to accurately vary the absorbance with the change in pathlength.
With near-perfect linear regression, the system can accurately measure a wide range of concentrations undiluted, ideal for process development, QC testing, and bioprocessing manufacturing risk mitigation.
The dedicated software’s MultiQ feature allows the user to measure the payload and antibody simultaneously.
The User Result feature allows for built-in calculations of the DAR value that doesn’t need to be done outside of the software.

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Application Services

Your success is our success

CTech is committed to our customers’ success. We design service offerings to supplement our standard support options and provide you with increased access to our highly knowledgeable and experienced professionals. We offer implementation, development, and educational guidance to maximize the benefits of your variable pathlength solutions and the Slope Spectroscopy^® technique.